Downstream Processing (DSP)
We use state-of-the-art equipment to develop simple and scalable processes envisioning large-scale cGMP manufacturing. We implement unit operations based on membrane processes which allow for efficient cell removal and concentration of the product from the insect cell production bulks.
Clarification & concentration
- microfiltration using dead-end depth filters
- membrane cassettes or hollow fibers for tangential crossflow filtration (micro- and ultrafiltration)
- preparative liquid chromatography systems, including an ÄKTA avant 150 that allows for efficient and fast chromatographic process screening and optimization based on Quality by Design approaches
- single-use or disposable materials are used due to a number of advantages, e.g., no cleaning and validation after utilization; particularly on chromatography we use disposable porous matrices based on membrane adsorbers and monoliths, especially suited for purification of large biologicals